Perhaps the greatest challenge facing today’s global leaders is the need to address the demand for a new strategic business orientation that effectively perceives the nature of complex markets and maximizes global business opportunities. This has given rise to the call for cultivating a Global Mindset (GM) as a foundation for global leadership. In this chapter we introduce a process for cultivating a GM based on a theory of Being-centered Leadership that proposes multiple levels of being as a context for effective global leadership.